Biological System
Renal & Metabolic
Kidney function and metabolite profiles across the mission
Overview
The kidneys regulate fluid balance, electrolytes, and waste clearance — functions that come under new stresses in space. The Comprehensive Metabolic Panel (CMP) gives a snapshot of kidney and liver function, electrolyte balance, and blood glucose across the mission window. The plasma metabolomics data from OSD-571 extends this picture to hundreds of circulating metabolites.
Key findings
- Creatinine and BUN (kidney filtration markers) stayed within clinical reference ranges for all crew.crew who showed this effect
- Electrolyte panels (sodium, potassium, chloride, CO2) were stable — no crew member showed clinically significant deviation.crew who showed this effect
- Plasma metabolomics (OSD-571) identified shifts in glutathione pathway metabolites and acylcarnitines at R+1.crew who showed this effect
- Glucose readings reflected pre-mission fitness levels — all crew maintained normal fasting glucose.crew who showed this effect
How to read this page: These findings describe four individuals at one point in time. No finding should be generalized to spaceflight health broadly. Individual differences dominate the signal. Values labeled “2× individual baseline” use derived thresholds, not clinical cutoffs.
Individual trajectories
change from own pre-mission level · n=4fold-change from L-44All crew · Renal & Metabolic●●●●Trajectory chart renders after preprocessing
CMP markers shown as change from own pre-mission level. Metabolomics charts will render once pathway processing is complete.